The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model
Identifieur interne : 002160 ( Main/Exploration ); précédent : 002159; suivant : 002161The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model
Auteurs : Hyun-Pil Lim ; Angel E. Mercado-Pagan [États-Unis] ; Kwi-Dug Yun ; Seong-Soo Kang [Corée du Sud] ; Taek-Hue Choi ; Julius Bishop [États-Unis] ; Jeong-Tae Koh ; William Maloney [États-Unis] ; Kwang-Min Lee [Corée du Sud] ; Yunzhi Yang [États-Unis] ; Sang-Won ParkSource :
- Journal of materials science. Materials in medicine [ 0957-4530 ] ; 2013.
Abstract
This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (
Url:
DOI: 10.1007/s10856-013-4939-9
PubMed: 23779152
PubMed Central: 4012921
Affiliations:
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Mercado-Pagan</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff><wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry></affiliation></author><author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name><affiliation wicri:level="1"><nlm:aff id="A3">College of Veterinary Medicine, Chonnam National University, Gwangju, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chonnam National University, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff><wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry></affiliation></author><author><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name><affiliation><nlm:aff id="A4">Department of Pharmacology and Dental Therapeutics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju</nlm:aff><wicri:noCountry code="subfield">Gwangju</wicri:noCountry></affiliation></author><author><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Materials Science and Engineering, Research Institute for Functional Surface Engineering, Chonnam National University, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Materials Science and Engineering, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University</nlm:aff><wicri:noCountry code="subfield">Chonnam National University</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of materials science. Materials in medicine</title><idno type="ISSN">0957-4530</idno><idno type="eISSN">1573-4838</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (<italic>p</italic><0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Choi, Taek Hue" sort="Choi, Taek Hue" uniqKey="Choi T" first="Taek-Hue" last="Choi">Taek-Hue Choi</name><name sortKey="Koh, Jeong Tae" sort="Koh, Jeong Tae" uniqKey="Koh J" first="Jeong-Tae" last="Koh">Jeong-Tae Koh</name><name sortKey="Lim, Hyun Pil" sort="Lim, Hyun Pil" uniqKey="Lim H" first="Hyun-Pil" last="Lim">Hyun-Pil Lim</name><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name><name sortKey="Yun, Kwi Dug" sort="Yun, Kwi Dug" uniqKey="Yun K" first="Kwi-Dug" last="Yun">Kwi-Dug Yun</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Mercado Pagan, Angel E" sort="Mercado Pagan, Angel E" uniqKey="Mercado Pagan A" first="Angel E." last="Mercado-Pagan">Angel E. Mercado-Pagan</name></region><name sortKey="Bishop, Julius" sort="Bishop, Julius" uniqKey="Bishop J" first="Julius" last="Bishop">Julius Bishop</name><name sortKey="Maloney, William" sort="Maloney, William" uniqKey="Maloney W" first="William" last="Maloney">William Maloney</name><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong-Soo" last="Kang">Seong-Soo Kang</name></noRegion><name sortKey="Lee, Kwang Min" sort="Lee, Kwang Min" uniqKey="Lee K" first="Kwang-Min" last="Lee">Kwang-Min Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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